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Due to the close relationship of Aranesp ä to endogenous erythropoietin, such a response is a theoretical possibility with Aranesp ä treatment, but has not been observed to date.

The difference in isoform ratio between Eprex and Binocrit could be due to the presence of more high-mannose structures in Binocrit compared to Eprex ().

National Comprehensive Cancer Network (NCCN) guidelines advised that ESAs were indicated to prevent transfusions among cancer patients receiving palliative, but not curatively intended, chemotherapy.

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ESA dose; ESAs do not improve quality of life; tumors may grow faster and death occur sooner with ESAs targeting high hemoglobin levels.

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Because a limited amount of EPO products was available, we were restricted to the common assays used for quality control: high performance size exclusion chromatography (HP-SEC) to assess monomer and aggregate content, ELISA to determine EPO protein content, SDS-PAGE under non-reducing conditions to detect possible fragmentation and covalent protein aggregates, capillary zone electrophoresis (CZE) for isoform profiling and a normocythemic mouse assay to test for potency.

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